Preparation of Arylmethylenesuccinates via Reaction of Arenecarbaldehydes with Wittig Reagent.

The Wittig Reaction

The Wittig Reaction

This so-called Wittig reaction has a number of advantages over other olefination methods; in particular, it occurs with total positional selectivity (that is, an alkene always directly replaces a carbonyl group). By comparison, a number of other carbonyl olefination reactions often occur with double-bond rearrangement. In addition, the factors that influence Eand Z-stereoselectivity are well un...

Mechanism of the Phospha-Wittig–Horner Reaction**

General. All reactions were performed under argon using Schlenk techniques. Diethyl ether and THF were freshly distilled from sodium/benzophenone prior to use. 1 H, 13 C and 31 P spectra were recorded on a 400 MHz and 300 MHz spectrometers. Chemical shifts (ppm) were reported and referenced to the internal signal of residual protic solvent. High resolution mass spectral analyses (HRMS) were per...

Reaction of sodium aminohippurate with Folin's reagent.

ITIS WELL RECOGNIZED that the Folin phenol method (1) for the determination of protein is not specific. This method was in fact originally standardized with protein or tyrosine, and the Folin phenol reagent was shown to react with numerous mono-, di-, and trihydroxyphenols in addition to other substances (s). Although most of these substances are not present in sufficient amounts to interfere w...

Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions.

A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied v...